These cells also appear abnormal in shape and size.
If you have ET, your marrow will show a significant increase in platelet-forming cells (megakaryocytes).
A bone marrow biopsy to remove a small amount of bone filled with marrow. A bone marrow aspiration to remove a liquid marrow sample. Several blood clotting tests are used to diagnose von Willebrand diseaseĪlthough a bone marrow examination isn't strictly necessary to make a diagnosis, doctors often use it to help confirm a ET diagnosis.īone marrow testing involves two steps usually performed at the same time in a doctor's office or a hospital: High platelet counts can limit how well the von Willebrand proteins clot. Blood contains many proteins that help the body stop bleeding, one of which is known as von Willebrand factor. Blood Clotting Tests: Patients with very high platelet counts may be tested for acquired von Willebrand disease, a blood disorder that can impair normal blood clotting and cause major bleeding. Although this test is not used to diagnose ET, if the results show that there is an abnormal amount of a particular substance in the blood, it may be a sign of disease or some other health problem. The test findings indicate how well a person’s kidneys, liver and other organs are working. These substances include electrolytes (such as sodium, potassium and chloride), fats, proteins, glucose (blood sugar), uric acid and enzymes. 
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Blood Chemistry Profile: This blood test measures the levels of certain substances released into the blood by organs and tissues in the body.In patients with ET, the platelets may appear enlarged and/or clumped together. The test also looks for the presence of immature (blast cells). Peripheral Blood Smear: A pathologist examines a small amount of blood under a microscope to see if there are any unusual changes in the size, shape, or appearance of the blood cells.In patients with ET, the platelet count is higher than normal. It also measures the amount of substance in the blood that carries oxygen (hemoglobin) and the percent of whole blood that is made up of red blood cells (hematocrit). Complete Blood Count with Differential: This test measures the number red blood cells, white blood cells and platelets in a sample of blood.Examine the patient's body for signs of disease.Listen to the patient's heart and lungs.During the physical examination, the doctor may:
History of thrombus (blood clot) or hemorrhagic events (loss of blood from damaged blood vessels)Īfter the medical history, the doctor will conduct a physical examination. Cardiovascular risk factors, such as high blood pressure and diabetes. The medical history should include information about the patient’s: Medical History and Physical ExaminationĮvaluation of an individual with suspected ET should start with a detailed medical history and a physical examination by a hematologist-oncologist Some of these tests may be repeated both during and after treatment to evaluate its effectiveness. It is important to have an accurate diagnosis, as it helps the doctor to: LOW MPV BLOOD TEST MAYO CLINIC SERIES
While certain signs and symptoms may indicate that a person has ET, a series of tests are needed to confirm the diagnosis. The Trish Greene Back to School Program.
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